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| Suetleflamumb | Дата: Пн, 26-Авг-13, 05:14:27 | Сообщение # 1 |
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| sypepypeOxine | Дата: Вт, 27-Авг-13, 00:28:26 | Сообщение # 2 |
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| sypepypeOxine | Дата: Вт, 27-Авг-13, 08:12:56 | Сообщение # 3 |
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| homGreedo | Дата: Пт, 30-Авг-13, 06:45:45 | Сообщение # 4 |
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| slewayGeafe | Дата: Пн, 02-Сен-13, 12:24:35 | Сообщение # 5 |
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| Triandine | Дата: Пн, 02-Сен-13, 23:42:43 | Сообщение # 6 |
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| Immalsiva | Дата: Пн, 23-Сен-13, 09:30:29 | Сообщение # 7 |
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| Nerbfavered | Дата: Сб, 28-Сен-13, 04:37:05 | Сообщение # 8 |
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| gepappeal | Дата: Сб, 28-Сен-13, 07:59:46 | Сообщение # 9 |
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| Nusemallvieme | Дата: Вт, 01-Окт-13, 09:36:34 | Сообщение # 10 |
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| Nusemallvieme | Дата: Чт, 03-Окт-13, 22:09:00 | Сообщение # 11 |
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Группа: Гости
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| cheeliDib | Дата: Вс, 18-Май-14, 10:00:40 | Сообщение # 13 |
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Группа: Гости
| обычно учу проектирование магистрального газа на этом сайте http://proekt-gaz.ru/load/4/ и еще советую.
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| tcsindustryn | Дата: Ср, 06-Июл-16, 07:53:24 | Сообщение # 14 |
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Группа: Гости
| Docetaxel (as generic or under the job name Taxotere) is a clinically well-established anti-mitotic chemotherapy medication (medication which interferes with cell division). It is hand-me-down mainly payment the treatment of breast, ovarian, prostate, and non-small cell lung cancer.[1 - [2 - [3 - Docetaxel has an FDA approved claim for treatment of patients who possess locally advanced, or metastatic titty or non small-cell lung cancer who partake of undergone anthracycline-based chemotherapy and failed to hold back cancer chain or relapsed[4 - and a European subscribe to to use in hormone-refractory prostate cancer.[5 -
According to a 2005 article in the quarterly Drugs, docetaxel administered as a one-hour infusion every three weeks commonly settled a ten cycle course, docetaxel is considered as or more basic than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.[1 - Extent the effectiveness of docetaxel versus paclitaxel and other taxanes is still controversial. A variety of more late-model articles be suffering with initiate "no confirmation that regimens containing docetaxel throw in the towel greater benefits than those including paclitaxel."[6 - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week charge slate old to be and is at rest considered efficient but hip studies are indicating a weekly schedule effect be better. A 2010 article in Prevailing Clinical Pharmacology states, "weekly government has emerged as the optimal schedule." Docetaxel is marketed worldwide comprised in the identify Taxotere by Sanofi-Aventis.[7 - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The transparent expired in 2010.[citation
Constitution
Docetaxel is of the chemotherapy opiate bearing; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an quotation from the bark of the rare Pacific yew tree Taxus brevifolia.[2 - Apt to inadequateness of paclitaxel, international delving was carried absent from unsurpassed to the formulation of docetaxel – an esterified yield of 10-deacetyl baccatin III, which is extracted from the renewable and readily present European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl essential coterie on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side sequence in place of of the benzyl amide in paclitaxel. The carbon 10 functional sort mutation causes docetaxel to be more bath-water soluble than paclitaxel.[2 -
Formulations and compositions
Docetaxel is a snowy right and is the strenuous ingredient handy in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 - [8 - The solution is a discernibly brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 - 20 mg Taxotere is distributed in a blister carton containing harmonious single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL infecund pyrogen-free anhydrous polysorbate 80, and a distinct dose Taxotere debt-free vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion shopping bag containing 0.9% sodium chloride or 5% glucose after administration.[8 - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and solvent vials are combined to bestow a solution of 10 mg/mL and the required measure is exhausted from this solution. Vials have an overfill to indemnify for liquid harm during preparation, foaming, adhesion to vial walls and the numb volume. 20 mg vials may be stored to 24 months below 25 °C away from insight and 80 mg vials as far as something 26 months in the nevertheless conditions.[8 -
Recently Sanofi has got sanction because of one-vial formulation.[citation needed - With this one-vial formulation, the preparation of the infusion answer is simplified during eliminating the blue ribbon dilution step. The two-vial and one-vial formulations in the same dose theme, docetaxel trihydrate, and the but excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous settling that contains the same psychedelic theme in the same concentration as the already approved two-vial formulation. The unmodified station, superiority, and sum of polysorbate 80 are closest in the infusion revelation of both formulations. The only remainder between these two formulations is the quantity of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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